March , 2024:

RESEARCH HIGHLIGHTS

Cryo-EM structure of the human TACAN in a closed state

Hemei Huang

TACAN is an ion channel-like protein that may be involved in sensing mechanical pain. Here, Chen et al. solved the cryo-EM structures of human TACAN in resting sate, suggesting that each protomer contains a putative ion conduction pore, and combined electrophysiological experiments and molecular dynamics simulations to determine the ion conduction pathw...

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